How Much Apigenin Should You Take for Sleep?
In recent years, apigenin has gained popularity as a natural sleep aid. But here's the problem: most supplements on the market contain doses far below what scientific studies suggest is effective for improving sleep.
So what’s the real dose that works? Let's dive in.
What Is Apigenin?
Apigenin is a natural flavonoid found in plants like chamomile and parsley. It’s studied for its calming, antioxidant, and anti-inflammatory effects, and most notably, its ability to activate GABA receptors—the same pathways targeted by prescription sleep medications.
But like any compound, the dose makes the difference between placebo and real effects.
What Does the Research Say About Apigenin for Sleep?
Animal and early human research suggests that meaningful sleep-promoting effects happen at higher doses.
-
Doses of 300 mg or more are where we begin to see clinical relevance for calming the nervous system and promoting sleep.
-
Most over-the-counter apigenin supplements range from 25 to 50 mg, which is unlikely to provide noticeable sleep support based on current evidence.
At Nice Supplement Co, we offer 300 mg of pure Apigenin 98%—providing a science-aligned dose in a single capsule.
Recommended Apigenin Dosage for Sleep
| Dosage | Likely Effectiveness |
|---|---|
| 25–50 mg | Minimal effect on sleep |
| 100 mg | May help some users mildly |
| 300 mg | Backed by clinical models for sleep & anxiety |
| 500 mg+ | Used in some research, generally safe anecdotally. |
If you're using apigenin specifically to improve sleep, 300 mg is where the clinical evidence points.
When to Take Apigenin for Sleep
We recommend taking 300 mg of Apigenin 98% 30 to 60 minutes before bedtime.
This allows time for the compound to engage with your GABA pathways and promote relaxation.
Apigenin's Broader Health Potential
Beyond sleep, Apigenin supports:
- Anti-inflammatory pathways
- Antioxidant protection
- NAD+ metabolism (a key anti-aging process)
- Neuroprotection and stress resilience
This makes apigenin a smart addition to your wellness stack—not just for better nights, but for better long-term health.
Is 300 mg of Apigenin Safe?
Clinical models suggest apigenin is well-tolerated at doses of 300 mg, with no serious side effects reported in healthy adults.
Why Nice Supplement Co Uses 300 mg
Most supplement brands stick to under-dosed products (25–50 mg) that fall short of what the science shows is needed for sleep.
We formulated our Apigenin 98% Capsules at 300 mg to provide a meaningful, effective dose, based on the latest research—not marketing fluff.
If you want to understand why we chose the dose we did you can read over the 2022 article “Our dosing of Apigenin for Anxiolytic, Sedative, and Sleep applications”. Take note, the industry standard 50mg ain't doing jack to help you sleep better.
Key Takeaways
✅ The effective dose for sleep is 300 mg of apigenin, not the 25–50 mg offered by most brands.
✅ Take apigenin 30–60 minutes before bed to help calm your nervous system.
✅ Apigenin also supports anti-aging, brain health, and inflammation control.
