In the second instalment of Making Synapses we discuss Caffeine, Historical use, Pharmacology of Caffeine - including what your body does with caffeine, and what caffeine does to your body. Following this, we talk tolerance and withdrawal considerations, then finishing off with some Day-to-Day chat and tips for using caffeine effectively as a tool in life and preventing dependency.
YouTube with Video
The roadmap of Making Synapses Ep.2 is as follows:
- Introduction and podcast roadmap (0.00);
- What is Caffeine and in what plants is it naturally occurring (1.55);
- Human use throughout history, controversy, and it's rise in popularity (3.30);
- Pharmacology of Caffeine (6.50);
- Dosing (7.20);
- Absorption from ingestion (8.20);
- Distribution throughout the body (8.45);
- Actions of caffeine as an adenosine receptor antagonist (11.00);
- What is Adenosine and its action (12.00);
- A1 Adenosine receptor (13.40);
- A2a Adenosine receptor (14.00);
- Effects of preventing Adenosine binding (14.45);
- Metabolism and clearance of caffeine from the body (17.40);
- Paraxanthine (18.50);
- Theobromine (19.30);
- Theophylline (20.05);
- Tolerance build (21.00);
- Withdrawal (22.20);
- Overdosing symptoms (23.20);
- General life considerations and practical take-homes (24.10);
- Reading from "This is your mind on plants" by Michael Pollan (28.43).
- "This is your mind on plants" by Michael Pollen, section 2 on Caffeine.
- Food Research International (2014), Pharmacokinetics of caffeine and its metabolites in plasma and urine after consuming a soluble green/roasted coffee blend by healthy subjects
- Clinical Pharmacology & Therapeutics (1995), Sympathomimetic effects of paraxanthine and caffeine in humans
- Journal of Neurochemistry (2008), An update on the mechanisms of the psychostimulant effects of caffeine
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